Botox was invented in 1895. The first attempt to isolate toxin was made in 1920 by Herman Sommer. In 1950, Dr Vernon Brooks found how Botulinum toxin (BTX) works by inhibiting acetylcholine.
In 1970, Dr Allan Scott was granted an approval by FDA to use the drug in strabismus patients. Allergan changed the name of the drug to botox and was granted an approval by FDA to use in strabismus patients in 1989. In 2002, the drug was granted an approval for use in the field of plastic surgery and particularly for facial applications.
Botox is produced by the bacterium clostiridium botulinum. It is anaerobic and found everywhere in nature.
It is divided into the following types: Α, Β, C1, D, E, F and G. Botox is either type A or any other type with the best activity.
It is neurotoxin and blocks the transmission of the nerve stimulus into motion from the relevant muscle.
Its application in Medicine
- Cervical dystonia
- Hemifacial spasm
- localized spasticity in childen with cerebral palsy
- post-stroke wrist and hand spasticity in adults
- primary axillary hyperhidrosis
- overactive bladder
Its application in plastic surgery
It applies in both men and women
- Lines between the eyebrows (glabella)
- Horizontal forehead lines
- Crow’s feet
- Loose neck
- Smokers line
Botox safety and clinical trials
It has been used for more than 30 years in Medicine and since 1998 in plastic surgery. It has been used in million of patients and in more than 4,000 clinical studies. Due to its high molecular weight it remains on the muscle it is placed, with minimal disperse.
Botox is used as frequently in men as in women.
The procedure is performed in the office by plastic surgeons. following
the full protocol, it lasts 10 minutes and entails no risk when done by